Relating Philip McAndrew, MD, Loyola University Wellness System smoking and physician cessation expert, that dream can easily become a nightmare without FDA product regulations. The simple truth is little is well known about the chemical substances e-cigarette smokers are inhaling. What’s known is there is an increase in the number of adolescents smoking them. ‘In our culture we have this notion that something new is something better regardless of how little we know about it or how little it's regulated,’ McAndrew said. ‘There is no clear evidence that e-smokes help with smoking cessation and having less FDA regulation has led to the use of at least 19 harmful chemical compounds in the products, some that are cancer-causing carcinogens.’ Related StoriesVanderbilt wins NIA grant to review efficiency of nicotine patch in improving memory loss in old adults with MCINew analysis shows nicotine increases codeine-induced analgesiaHenry Ford Medical center pulmonologist advocates for raising the smoking age to 21 The e-smoking cigarettes contain nicotine, but a high focus of propylene glycol also, which is a hazard if inhaled.Metastasis-free and Disease-free survival data are provided in Figure 1A and 1B in the Supplementary Appendix. Discussion In this randomized, stage 3 trial with a median follow-up of 69.9 months, the addition of chemotherapy to standard-dose radiotherapy was connected with a relative reduction of 33 percent in the chance of locoregional recurrence with a reduced amount of almost 50 percent in invasive recurrence. This benefit appeared constant in preplanned subgroup analyses and had not been affected by a brief history of earlier neoadjuvant chemotherapy, which suggests that concomitant and neoadjuvant chemotherapy confer individual benefits on distant and local control, respectively. The improvement in locoregional control was accomplished with modest boosts in acute toxic results that didn’t reach statistical significance with respect to grade three or four 4 outcomes.