Adolor initiates second ADL5945 Phase 2 study in opioid-induced constipation Adolor Corporation today announced that it is initiating a second Phase 2 research of ADL5945 in chronic non-cancer pain individuals experiencing opioid-induced constipation .10 mg and 0.25 mg) each administered twice daily in sufferers with OIC. This second Stage 2 research of ADL5945, that may assess a single dosage of 0.25 mg once daily versus placebo in the same research design, is intended to complete the dosing assessment of ADL5945 in anticipation of a Phase 3 program. ‘The addition of the once-daily dosing research will expand our knowledge of the efficacy, safety and tolerability of ADL5945, and the effective completion of the Stage 2 plan should enable us to select a dose for pivotal confirmatory studies,’ said Michael R.
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