Our research is the first to show an inflammatory mechanism by which high ocular pressure causes eyesight reduction in acute glaucoma individuals, said co-senior writer Kang Zhang, MD, PhD and professor of ophthalmology. The second leading reason behind irreversible blindness globally, glaucoma identifies several eye diseases connected with elevated intraocular pressure broadly classified as either open-angle or closed-angle. Open-angle may also be called the silent thief of sight due to its slow, often overlooked progression. By contrast, acute closed-angle glaucoma frequently is a painful ophthalmologic emergency in which there is a unexpected rise in eye pressure and immediate harm to eyesight.The products correspond to those of enzymatic cleavage that create a mature miRNA duplex , whereas the D1709A enzyme generated only the 18-nucleotide product, as expected.10,11 This finding indicates that the 22-nucleotide band comes from activity at the RNase IIIb site, whereas the 18-nucleotide band relates to activity at the RNase IIIa site. The hot-place mutant DICER1 proteins yielded markedly low degrees of the 22-nucleotide item and substantial degrees of the 18-nucleotide product, suggesting that, like the D1709A mutation, the D1709N, D1709E, and E1705K substitutions bring about decreased RNase IIIb activity but retention of RNase IIIa activity. 8 in the Supplementary Appendix). We also observed hot-spot mutations in a single high-grade ovarian carcinosarcoma, one testicular germ-cell tumor, and two embryonal rhabdomyosarcomas.