Advaxis’ Listeria based fusion protein granted U here .S. Patent The US Patent and Trademark Workplace has issued Advaxis, Inc. Advaxis has patents on two groups of antigen-fusion proteins based upon the Listeria proteins Act-A and LLO. Act-A may have nonspecific immune stimulating adjuvant properties. Immune tolerance happens when repeated immunogenic stimulation results in fatigue of the immune system and an inability to mount a therapeutic response. An agent such as for example an Act-A antigen fusion proteins has the capability to generate a therapeutic anti-tumor immune response; even in the presence of pre-existing immune tolerance.
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