Concussions are a result of a traumatic brain injury that causes a disruption of the brain function. Disruption of neurologic function can manifest itself with a variety of symptoms, including headaches, loss of consciousness, memory and concentration disturbances, dizziness, nausea/vomiting and confusion. ‘What symptoms a person experiences depends on how the brain techniques within the skull because of the damage,’ said Coates. ‘Everyone is different and how a person responds after mind trauma is variable. Symptoms can last for some hours or almost a year.’ Related StoriesDiagnosing traumatic human brain injury through a blood test: an interview with Dr KorleyWhy do we sleep? An interview with Professor WisdenCharles Bonnet syndrome: an interview with Dr.Serious adverse events were reported in 1.1 percent of individuals receiving placebo . Through the 12-week treatment period, discontinuation of treatment due to adverse occasions was higher among the linaclotide-treated individuals, happening in 7.2 percent of sufferers receiving placebo, and was primarily a result of an increased rate of discontinuation due to diarrhea in those groups . For some of the patients, the 1st occurrence of diarrhea was reported through the initial 2 weeks of therapy . A complete of 13 of the 852 patients who received linaclotide had diarrhea that was graded by the investigator as severe, as compared with 1 of 424 sufferers who received placebo. There were no significant variations in hematologic results or blood chemical ideals clinically, results on urinalysis, electrocardiographic outcomes, or vital signs between the placebo and linaclotide groupings.