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AMP-activated protein kinase essential contributor to brain growth An enzyme researchers have studied for years because of its potential connections to cancer, diabetes, cardiovascular disease, hypertension and stroke, appears to have yet another major role to play: helping create and maintain the mind. When scientists at Washington University College of Medication in St generic cialis . Louis selectively disabled the enzyme AMP-activated proteins kinase in mouse embryos, overall brain size was decreased by 50 %, the cerebrum and cerebellum were shrunken, and the mice died within three weeks of birth. Experts showed that the version of AMPK they disabled was essential to the survival of neural stem cells that induce the central nervous program.