A technetium-99m nuclear thyroid uptake scan and measurement of thyroid receptor antibodies are the most useful preliminary investigations for determining the reason for hyperthyroidism, if it’s not apparent clinically. Treatment of hyperthyroidism usually involves antithyroid medications , radioactive iodine or total thyroidectomy. Careful up-titration of thyroxine dosage is usually required in treatment of hypothyroidism. Thyroid dysfunction in pregnancy can be an important clinical scenario and requires expert involvement.The randomized, double-blind, placebo-controlled clinical trial is normally underway at 16 centers in the usa currently. The medical trial has received approximately $5.9 million in grant funding to date. Currently, 54 out of 60 topics have been enrolled in the Zinthionein clinical study testing the therapeutic effects of Adeona's proprietary oral, gastro-retentive, sustained-launch zinc and cysteine formulation on cognition in Alzheimer's disease and mild cognitive impairment subjects. The randomized, double-blind, placebo-controlled study is underway at 3 centers in the usa currently. Study subjects are becoming assessed at 3 and 6 months for serum parameters of zinc and copper as well as adjustments in cognitive function using standard Alzheimer's disease scientific tests.